There are a few circumstances in which I'd do it, but they involve your being either unconscious or delirious. A good, set-in infection will cause one or the other sooner or later, so we might as well save time and do it now.

[He's protesting her doing it right at the open bar. Good, that means she can pivot to "do it somewhere else" over "not doing it at all."]

I'm happy to go somewhere more private, and more comfortable for you. Contrary to popular belief, most drinking alcohol isn't suitable for disinfectant purposes.